Note: Javascript is disabled or is not supported by your browser. The acute (short-term) effects of ethylene oxide in humans consist mainly of central nervous system (CNS) depression and irritation of the eyes and mucous membranes. Ethylene oxide has caused statistically significant increases in mononuclear cell leukemia in female Fischer 344 rats. Ethylene oxide (EO) is widely used in the health care industry as a gas sterilant for medical products that cannot withstand the high temperature and humidity associated with conventional steam sterilization. Occupational exposure can occur during ethylene oxide gas … A Review and Evaluation of Human Genetic Bioassay Data for Some Known or Suspected Human Carcinogens. It is a clear, colorless liquid below its boiling point of 10 degrees C. It is explosive when heated or in the presence of alkali metal hydroxides and catalytic surfaces. Ethylene oxide is also used as a fumigant and sterilant for microbial organisms in a variety of applications. Chromosome analysis of lymphocytes from workers at an ethylene oxide plant. Chromosomal aberrations and micronuclei in lymphocytes in relation to alkylation of hemoglobin in workers exposed to ethylene oxide and propylene oxide. 1995). Ethylene oxide (EO), an industrial intermediate and gaseous sterilant for medical devices, is carcinogenic to humans, which warrants minimization of exposure in the workplaces. It dissolves easily in water.Ethylene oxide is a man-made chemical that is used primarily to make ethylene glycol (a chemical used to make antifreeze and polyester). Detection of Effects of Mutagens in Human Populations. Ethylene oxide causes acute poisoning, accompanied by the following symptoms: slight heartbeat, muscle twitching, flushing, headache, diminished hearing, acidosis, vomiting, dizziness, transient loss of consciousness and a sweet taste in the mouth. (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted canister providing protection against ethylene oxide*; or Any self-contained breathing apparatus with a full facepiece; or Any supplied-air respirator with a full facepiece. and you may need to create a new Wiley Online Library account. Incidental exposure may also increase sister chromatid exchange. * This chemical is on the Special Health Hazard Substance List because it is FLAMMABLE and REACTIVE. Central nervous system effects are frequently associated with human exposure to ethylene oxide in occupational settings. Effects On Humans and Animals. Evaluation in Man and Animals of Tests for the Detection of Population Exposures to Genotoxic Chemicals. Inhibition of Root Growth 6. Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV. Ethylene oxide is a known mutagen as indicated by short‐term testing in vitro and in vivo. The physiological effects are: 1. Objective: The influence of the polymorphic human glutathione-S-transferase (GST) T1 and M1 genotypes (classified as "conjugators" and "nonconjugators") on the biological effects of nonoccupational ethylene oxide exposure as reflected by the formation of globin N2-hydroxyethylvaline adducts was investigated. Garry VF, Hozier J, Jacobs D, Wade RL, Gray DG. Unexpected decrease in cytogenetic biomarkers frequencies observed after increased exposure to organophosphorus pesticides in a production plant. 4 PART 1, p. 544-546. 0.2.1.1 ACUTE EXPOSURE. Human diploid VH-10 fibroblasts were pre-exposed to γ-rays and then treated with ethylene oxide (EtO). Ethylene modulates calcium regulation and other functions in animal cells. Specific attention was paid to smoking as a potential source of exposure. To study the problem in a hospital sterilization facility where occupational exposure was suspected, epidemiologic, analytic, and bioassay tools were employed. Chromosomal aberrations in mouse lymphocytes exposed in vivo and in vitro to aliphatic epoxides. ethylene glycol provided in the expert panel report, the public comments, and additional scientific information available since the expert panel meeting. OBJECTIVE: To study the hazards of demulsifier production process. Harmful effects of ethylene oxide on humans, stringent government regulation guiding the application of ethylene oxide on polyester fiber and TEP resin and rise in health issues are the significant factors expected to obstruct the growth of global ethylene oxide market during the forecast period. International Archives of Occupational and Environmental Health. To determine the minimum sterilization time required and the effect of ethylene oxide on bone's osteoinductive capacity and chemical structure, samples were exposed to ethylene oxide for different times (5-240 min). Non-Human Toxicity Values; Ecotoxicity Values; Soil Adsorption / Mobility; Volatilization; Ethylene Oxide CAS RN: 75-21-8 Health Effects. Although humans and animals may differ in their susceptibility to specific chemical compounds, any substance that produces cancer in experimental animals should a… Garry VF, Hozier J, Jacobs D, Wade RL, Gray DG. Chronic (long-term) exposure to ethylene oxide in humans can cause SCE increases after an accidental acute inhalation exposure to EtO and recovery to normal after 2 years. Ethylene oxide (EtO) is produced in large volumes and is primarily used as an intermediate in the production of several industrial chemicals, the most notable of which is ethylene glycol. Chromosome aberrations in individuals occupationally exposed to ethylene oxide, and in a large control population. Ethylene oxide is a known mutagen as indicated by short‐term testing in vitro and in vivo. Cytogenetic Monitoring of Human Populations. Ethylene Oxide (EtO) is a common gas used for low temperature sterilization. It also increases the risk of breast cancer in women. Leaf … In some persons, ethylene oxide exposure may result in allergic sensitization, and future exposure may cause hives or a life-threatening allergic reaction. If you do not receive an email within 10 minutes, your email address may not be registered, ETHYLENE OXIDE: ICSC: 0155: 1,2-Epoxyethane Oxirane Dimethylene oxide: July 2015: CAS #: 75-21-8: UN #: 1040 EC Number: 200-849-9 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Extremely flammable. et al., «IgE against ethylene oxide-altered human serum albumin in patients who have had acute dialysis reactions.» Journal of Allergy and Clinical Immunology. The NTP brief is intended to provide clear, balanced, scientifically sound information on the potential for ethylene glycol exposures to result in adverse effects on human The incidence of this disease in the exposed females increased linearly with dose. Perspectives in Basic and Applied Toxicology. Ethylene Oxide 75-21-8 Hazard Summary The major use for ethylene oxide is as a chemical intermediate in industry. Sister-chromatid exchange induction in peripheral blood lymphocytes of rats exposed to ethylene oxide by inhalation. The International Agency for Research on Cancer (IARC) and the United States Environmental Protection Agency (USEPA) classified EtO as a known human carcinogen. Triple Response 4. Author information: (1)Binzhou Center for Disease Control and Prevention, Binzhou 256618, China. Adverse health effects of ethylene oxide and occupational exposure limits. Individual Susceptibility to Genotoxic Agents in the Human Population. Previous article in issue: Genetic effects of strong magnetic fields in drosophila melanogaster: I. Homogeneous fields ranging from 13,000 to 37,000 gauss . Ethylene oxide is a known mutagen as indicated by short-term testing in vitro and in vivo. 1, 3-butadiene, ethylene oxide and vinyl halides (vinyl fluoride, vinyl chloride and vinyl bromide). Ethylene Effects On Humans. It dissolves easily in water. Ethylene oxide is a known mutagen as indicated by short‐term testing in vitro and in vivo. Assessing the Feasibility of Retrospective Cohort Studies. Ethylene oxide is known to be a human carcinogen based on evidence from studies in humans and experimental animals and from supporting mechanistic data. In the reverse experiment, the cells were pretreated with EtO and then exposed to γ-rays. Genetic Bioassay Data on Some Known or Suspected Human Carcinogens. Use of Biochemical and Molecular Biomarkers for Cancer Risk Assessment in Humans. [Effects of ethylene oxide and propylene oxide on human health]. Alkylation of DNA and hemoglobin in the mouse following exposure to propene and propylene oxide. Profile for ethylene oxide, Toxicological Sister chromatid exchanges induced in rabbit lymphocytes by ethylene oxide after inhalation exposure. Children experiencing the effects of chronic exposure to Ethylene Oxide can be significantly more severe than the damage caused to adults due to its human carcinogen properties. ToxFAQs™ for Ethylene Oxide. Effects of Long-Term (Chronic) Exposure: Can cause dry, red, cracked skin (dermatitis) following skin contact. Another group of eight persons with fewer complaints studied as late as the ninth week showed significantly increased exchanges. Some of the BAD effects of Ethylene are to cause vegetables to go yellow, bud damage in dormant nursery stock, drop off of leaves in ornamentals and rapid death of most cut flowers. Mutagenicity testing in environmental toxicology. Draft Toxicological Profile for Chlorine Dioxide and Chlorite. OBJECTIVE: To study the hazards of demulsifier production process. Learn more. It is a colorless, poisonous gas that attacks the cellular proteins and nucleic acids of microorganisms. ET has not produced evidence of cancer in laboratory animals and is “not classifiable as to its carcinogenicity to humans” (IARC, Group 3). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; World Health Organization. Ethylene oxide [MAK Value Documentation, 1993]. Laboratory a… Review of the mutagenicity of ethylene oxide. One fundamental question is whether plant ethylene production has a xenohormetic effect (cross-species hormonal effect) on animals that consume them. 1.7 What recommendations has the federal government made to protect human health? Biologic monitoring of exposure to chemical mutagens in the occupational environment. The Rationale and Methodology for Quantifying Sister Chromatid Exchange in Humans. The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents. Closed system, ventilation, … Download Citation | [Effects of ethylene oxide and propylene oxide on human health] | To study the hazards of demulsifier production process. The DHHS has determined that ethylene oxide is known to be a human carcinogen (NTP 2011). Number of times cited according to CrossRef: Biological Monitoring in Surveillance of Exposure to Genotoxicants. 1.3 How can ethylene oxide enter and leave my body? Working off-campus? Mutation Research/Genetic Toxicology and Environmental Mutagenesis. Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III. Learn about our remote access options, Section of Health Risk Assessment, Minnesota Department of Health, Minneapolis, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Department of Surgery, Hennepin County Hospital, Minneapolis. REASON FOR CITATION * Ethylene is on the Hazardous Substance List because it is cited by ACGIH, DOT, DEP, NFPA and EPA. SUMMARY AND EVALUATION 2.1 Human Exposure to Ethylene Oxide Human exposure occurs mainly through inhalation in sterilization facilities and in production plants. 1.2 How might I be exposed to ethylene oxide? 1.6 Is there a medical test to determine whether I have been exposed to ethylene oxide? Ethylene oxide has besides its toxic reaction a mutagenic effect upon human fibroblasts. For this reason, some items on this page will be unavailable. Janice W. Yager, Effect of concentration—time parameters on sister-chromatid exchanges induced in rabbit lymphocytes by ethylene oxide inhalation, Mutation Research/Environmental Mutagenesis and Related Subjects, 10.1016/0165-1161(87)90076-8, 182, 6, (343-352), (1987). Headache, nausea, and vomiting have been reported. The Interaction between Epidemiology and Animal Studies in Industrial Toxicology. The EPA and the federal Department of Health and Human Services both consider EtO a human carcinogen. Biological monitoring in surveillance of exposure to genotoxicants. Learn about ethylene oxide, which can raise your risk of lymphoma and leukemia. Ethylene oxide caused dose-related increases in the frequency of he-moglobin adducts in exposed humans and rodents. Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats. Historically, ethylene glycol has been commercially produced on a large-scale ba-sis by hydration of ethylene oxide. Currently, it is also produced by the oxidation of ethylene in the presence of acetic acid to form ethylene diacetate, which is then hydrolysed to the … Neurotoxicological evaluation of hospital sterilizer workers exposed to ethylene oxide. Mortality among Workers Exposed to Ethylene Oxide. Provides exposure risks, exposure limits, and health effects for ethylene oxide. This is why I would NEVER buy flowers from a Petrol station as their life would be at least reduced by two thirds due to the ethylene from car exhausts. Ethylene oxide (EO) is an important industrial chemical that is classified as a known human carcinogen (IARC, Group 1). Sister chromatid exchanges and DNA repair capability in sanitary workers exposed to ethylene oxide: Evaluation of the dose‐effect relationship. Ethylene oxide is an alkylating agent; it has irritating, sensitizing and narcotic effects. 0.2.1 SUMMARY OF EXPOSURE. Cytogenetic, immunological, and haematological effects in workers in an ethylene oxide manufacturing plant.. Human Cytogenetic Monitoring: Occupational Exposure to Ethylene Oxide. Statistical model for prediction of retrospective exposure to ethylene oxide in an occupational mortality study. May 28, 2018 - Ethylene oxide may have negative effects on humans and the environment ☆ READ MORE ☆ Scan your favorite products for toxic ingredients. Genetic Toxicology of Some Known or Suspected Human Carcinogens. An Integrated Approach to Human Monitoring. May cause an allergic skin reaction in some people. It is also an irritant to skin and the respiratory tract, and inhaling the vapors may cause the lungs to fill with fluid several hours after exposure. The dangerous side effects and human carcinogen health risks involved in the use of Ethylene Oxide have mostly been hidden from public view. An Evaluation of Possible Effects on Health Following Exposure To Ethylene Oxide. 10.1002/1520-6866(1990)2:2<137::AID-TCM1770020204>3.0.CO;2-4. ethylene oxide in humans can cause irritation of the eyes, skin, nose, throat, and lungs, and damage to the brain and nervous system. Risk of fire and explosion as a result of decomposition when heated. Sister chromatid exchange frequency in workers exposed to high levels of ethylene oxide, in a hospital sterilization service. Formation of Adventitious Roots and Root Hairs 5. Ethylene oxide is a flammable gas with a somewhat sweet odor. * Ethylene Oxide sterilization Over 20,000 healthcare facilities worldwide use Ethylene oxide sterilizers to process sensitive instruments which cannot be adequately sterilized by other methods. Ethylene oxide causes acute poisoning, accompanied by a variety of symptoms. Toxicological Risk Assessment and Oncodynamics of Ethylene Oxide as Related to Occupational Exposure. Email: Contact CDC-INFO. Source: ... Because side effects of acute ethylene oxide exposure can occur up to 72 hours after exposure, anyone who suspects exposure should go to a medical facility for evaluation. 1. Studies on Mechanisms of Carcinogenesis Ethylene oxide is a direct-acting alkylating agent that forms adducts with biological macromolecules, including hemoglobin and DNA. Volume 97. Sister-chromatid exchange: second report of the Gene-Tox program. 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