Injection of XIAFLEX ® into collagen-containing structures such as tendons or ligaments of the hand may result in damage to those structures and possible permanent injury such as tendon rupture or ligament damage. If you still have the cord, the doctor may try to extend the treated finger(s) and “break” the cord. If you have more than 1 contracture, your doctor may give you 2 injections in 1 of your hands during your visit, Advise you to keep your hand elevated until bedtime, Advise you to limit the movement of your treated finger(s), Ask you to do simple finger exercises daily after the procedure, Advise you how long to wait before resuming normal activities with the treated hand, Return to the doctor about 30 days after the injection to have your finger(s) examined, Depending on your results, or if the cord(s) is still present, you may need additional injections and finger extension procedures (up to 3 times per cord), approximately 4 weeks apart, Signs of infection after your injection, such as fever, chills, increased redness, or swelling, Numbness or tingling in the treated finger(s), Trouble bending the injected finger(s) after the swelling goes down, Tears in the skin of your treated finger(s), swelling of the injection site or the hand, bruising or bleeding at the injection site, pain or tenderness of the injection site or the hand, swelling of the lymph nodes (glands) in the elbow or armpit. MP=metacarpophalangeal Individual results may vary, This patient had a cord that could be felt causing a contracture of the PIP joint of the left pinky finger. Afterward, they report side effects and complications that were far worse than they were prepared for. Upland California Orthopedic Surgeon Doctors physician directory - Dupuytren's contracture treatment options include Xiaflex injection, needle aponeurotomy, ultrasound, and cortisone injection. For more information about how Endo Pharmaceuticals protects personal information about you, please read our Privacy Policy at www.endo.com/privacy-legal. BioSpecifics Technologies Corp., a biopharmaceutical company developing first in … Since 2002 our position has always been to recommend surgical intervention in those cases that have not responded to an aggressively applied round of conservative Alternative Medicine therapy. Observation. In the controlled and uncontrolled portions of clinical trials in Dupuytren's contracture, flexor tendon ruptures occurred after XIAFLEX ® injection. Learn about causes, risk factors, and symptoms. Actual patient. Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. If the disease progresses slowly, causes no pain and has little impact on your ability to use your hands for everyday tasks, you might not need treatment. If you have any questions, talk to your doctor. Learn causes, risk factors, and symptoms. Nerve Injury. Malvern, PA 19355, XD-05939/September 2020 www.xiaflex.com 1-800-462-ENDO (3636). A hand specialist may consider XIAFLEX® if you have Dupuytren's contracture with a cord that can be felt. These are not all of the possible side effects with XIAFLEX®. There is a risk of anaphylactic … In these 2 clinical studies, patients received up to 3 injections of XIAFLEX® or placebo into a cord that could be felt on Days 0, 30, and 60. Please see the full Prescribing Information, including Medication Guide. Move each finger from side to side (like a windshield wiper) one at a time; repeat 10 times. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger. If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. XIAFLEX should be administered by a healthcare provider experienced in injection procedures of the hand and in the treatment of patients with Dupuytren’s contracture. The following steps can help you better understand what to expect. XIAFLEX® is a registered trademark of Endo International plc or one of its affiliates. The cord was injected with XIAFLEX® and a finger extension procedure was performed 48 hours later, PIP=proximal interphalangeal Individual results may vary, Treatment of two contractures on the same hand, This patient had a cord that could be felt causing contractures of the MP and PIP joints of the left pinky finger. XIAFLEX ® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. They all believed Xiaflex is as good non-surgical treatment for Dupuytren’s contracture. The results of this medical treatment without surgery are surprising. XIAFLEX ® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. Next day cord break left open wound which could not be stitched and took several weeks to heal. The patient leaflet for Xiaflex lists considerations when caution must be taken for using this treatment: known allergy to the ingredients. XIAFLEX approved in Japan for treatment of patients with Dupuytren's contracture. Contractures that have come backDupuytren’s contracture may come back no matter what option you use. The Xiaflex procedure helps many Dupuytren’s contracture patients. Repeat the exercise 4 times a day. © 2019 Endo Pharmaceuticals Inc. All rights reserved. You are now leaving the XIAFLEX® website. The most common side effects with XIAFLEX® for the treatment of Dupuytren’s contracture include swelling of the injection site or the hand; bruising or bleeding at the injection site; pain or tenderness of the injection site or the hand; swelling of the lymph nodes (glands) in the elbow or armpit; itching; breaks in the skin; redness or warmth of the skin; pain in the armpit. Repeat the exercise 4 times a day. Use the unaffected hand to gently straighten the affected finger 10 times, holding for 5 to 10 seconds. This condition causes an abnormal thickening of the tissue in the palm of the hand. Learn about causes, risk factors, and symptoms. Arch your knuckles back 10 times in a row. Images used with permission from physician and patient. XIAFLEX® is an FDA-approved, nonsurgical treatment for adults with Dupuytren’s contracture when a “cord” can be felt. https://www.webmd.com/drugs/2/drug-153667/xiaflex-injection/details User Reviews for Xiaflex to treat Dupuytren's contracture Xiaflex has an average rating of 2.0 out of 10 from a total of 12 ratings for the treatment of Dupuytren's contracture. Click CONTINUE if you are a healthcare professional. Repeat this exercise 4 times a day. This can be done in several ways. Learn about causes, risk factors, and symptoms. XIAFLEX® should be injected by a healthcare provider who is experienced in injection procedures of the hand and treating people with Dupuytren's contracture. Twenty four hours later the patient returns to the office for the doctor to forcefully break the cords that were enzymatically weakened the day before, by taking the fingers into extension Dupuytren's Contracture - Treatment Comparison Chart. Patients had finger extensions performed by a physician; were fitted with a splint; and were instructed to use a splint at bedtime for up to 4 months and perform daily finger exercises. TREATMENT COMPARISON CHART. If you still have the cord, the doctor may try to extend the treated finger(s) and “break” the cord. The cord was injected with XIAFLEX® and a finger extension procedure was performed 48 hours later. Bend only the top 2 joints of all fingers, keeping your knuckles straight. Using XIAFLEX® with certain other medicines can cause serious side effects. For more information, ask your healthcare provider or pharmacist. Endo Pharmaceuticals is not responsible for the content of linked sites. Treatment with XIAFLEX® is performed in a doctor’s office. Please see the full Prescribing Information, including Medication Guide. Patients also performed finger exercises every day. After the extension procedure, the doctor will: Your first follow-up visit with the doctor will be approximately 1 to 3 days after the injection. You may wish to follow the progression with a tabletop test, which you can do on your own.Treatment involves removing or breaking apart the cords that are pulling your fingers toward your palm. It is not known if XIAFLEX ® is safe and effective in children under the age of 18. The following are examples of finger exercises you can do at home. The information contained in this section of the site is intended for US healthcare professionals only. Treatment for Dupuytren's contracture depends on the severity of your condition. Over the course of Dupuytren's disease, fibrous tissue in the palm thickens and tightens. XIAFLEX® can cause serious side effects, including: Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Endo Pharmaceuticals Inc. is committed to respecting the privacy of its website visitors. XIAFLEX, supplied as a lyophilized powder, must be reconstituted with the provided diluent prior to use [see Dosage and Administration (2.1)] . XIAFLEX® is indicated for the treatment of adult patients with Dupuytren's contracture with a palpable cord. A hand specialist may consider treatment with XIAFLEX® if you have a cord that can be felt, along with: Contractures ranging from less severe to more severe. I had procedure involving 3 shots to correct Dupuytrens contracture in right hand, small finger. 8% of those users who reviewed Xiaflex reported a positive effect, while 92% reported a negative effect. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). Xiaflex® TREATMENT Today there is an FDA approved treatment for Dupuytren’ contracture with a medication called Xiaflex that is proving to be highly effective. © 2021 Endo Pharmaceuticals Inc. All rights reserved. XIAFLEX ® is indicated for the treatment of adult patients with Dupuytren's contracture with a palpable cord. In these 2 studies, 60% of patients had a straight or nearly straight finger 30 days after the last injection on Days 30, 60, or 90 after up to 3 XIAFLEX® injections and finger extension procedures compared with 6% of patients who received placebo. It is not known if XIAFLEX ® is safe and effective in children under the age of 18. … Ask a hand specialist if XIAFLEX® is right for you. In the controlled and uncontrolled portions of clinical trials in Dupuytren's contracture, flexor tendon ruptures occurred after XIAFLEX, In the controlled portions of the clinical trials in Dupuytren's contracture, a greater proportion of XIAFLEX. Malvern, PA 19355 Dupuytren disease is a systemic disorder which most visibly affects the hands. Please see the full Prescribing Information, including Medication Guide. Shots were very painful and syringe supplied by Endo "blew apart" on 2 nd shot. Repeat 10 times. The doctor may use local anesthetic during this procedure. This is to help straighten your finger(s). This is to help straighten your finger(s). XIAFLEX® is a registered trademark of Endo International plc or one of its affiliates. Tell your healthcare provider if you have any side effect that bothers you or does not go away. Real Xiaflex patients tell what happened While certainly not exhaustive, this chart gives the highlights of the pros and cons of each treatment method. XIAFLEX is used for the treatment of Dupuytren’s contracture in adult patients with a palpable cord. XIAFLEX® can cause serious side effects such as tendon rupture or ligament damage. Treatment for adults with Dupuytren’s contracture with a palpable cord, Important Safety Information for XIAFLEX®. Studies show that prescription XIAFLEX®, along with a finger extension procedure, may help straighten or nearly straighten the affected finger and improve range of motion after up to 3 injections. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®. Irvine California Orthopedic Surgeon Doctors physician directory - Dupuytren's contracture treatment options include Xiaflex injection, needle aponeurotomy, ultrasound, and cortisone injection. Repeat the exercise 4 times a day. The traditional "treatment" recommendation for people with this condition was to wait … Use these questions to help guide your discussion with a hand specialist. A Dupuytren's contraction is caused by an abnormal accumulation of collagen (scar) in the tissue beneath the skin of the palm of the hand. Xiaflex treatment of a Dupuytren cord requires a doctor to make multiple injections of Xiaflex into the palm of the hand into the Dupuytren’s cord at various points. For treatment of Dupuytren’s contracture, the patient needs to be experiencing a cord-like fibrous growth in order for Xiaflex to be effective in treating the condition. It starts breaking down the cord as soon as you receive the first injection. The doctor may use local anesthetic during this procedure. It is not known if XIAFLEX ® is safe and effective in children under the age of 18. It is not known if XIAFLEX® is safe and effective in children under the age of 18. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure. XIAFLEX ® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. Multiple contractures in 1 handUp to 2 cords in 1 hand may be treated during 1 office visit. Please see the full Prescribing Information, including Medication Guide. Considering treatment with XIAFLEX®? It is used for treating Dupuytren's contracture. Note: Dupuytren’s contracture may return no matter what treatment is used. XIAFLEX® should be injected by a healthcare provider who is experienced in injection procedures of the hand and in treating people with Dupuytren’s contracture. Evansville Indiana Orthopedic Surgeon Doctors physician directory - Dupuytren's contracture treatment options include Xiaflex injection, needle aponeurotomy, ultrasound, and cortisone injection. Privacy/Legal  XD-05702/February 2019  www.xiaflex.com 1-800-462-ENDO (3636). *, *In 2 clinical studies, patients were asked to rate their satisfaction with treatment on Day 90 as “very satisfied,” “quite satisfied,” “neither satisfied nor dissatisfied,” “quite dissatisfied,” or “very dissatisfied.” For data analysis, “satisfied” includes patients who chose “very satisfied” or “quite satisfied.”. Instead, you can wait and see if Dupuytren's contracture progresses. Dupuytren's Contracture Treatment Xiaflex. Xiaflex is used to treat Dupuytren's contracture in adults. Xiaflex, a treatment by injecting collagenase enzymes in the palm of the affected hand is now available in Canada. On top of these kind of bad reactions, it is also coming out that Xiaflex has the worse recurrence rate of all the medical treatments for Dupuytren’s contracture; this means the Dupuytren’s contracture comes back faster and sooner after the Xiaflex procedure than after traditional hand surgery. XIAFLEX ® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. The complication of Dupuytren's treatment most feared by surgeons is usually a nerve … In studies, patients received up to 3 injections of XIAFLEX® or placebo into a cord that could be felt at approximately 4-week intervals. Currently, there are treatments for hand deformities caused by Dupuytren disease (“Dupuytren contracture”), but no treatment for the underlying process of Dupuytren disease. Please see the full Prescribing Information, including Medication Guide. This information should not take the place of talking with your doctor or healthcare professional. The most common side effects with XIAFLEX® in these studies were swelling of the injected hand and bruising or bleeding at the injection site. Many Canadian patients have had the chance to benefit from this treatment. About 24 hours after each injection, patients had a finger extension procedure and were fitted with a splint to wear at bedtime for up to 4 months. This bending is called a contracture and is caused by the abnormal formation of a cord(s) containing collagen under your skin. In: Biologics, Collagenase, Dupuytren's, Dupuytren's Contracture, Dupuytren's Disease, Xiaflex Feb 17, 2010 Auxilium has moved closer to product availability of Xiaflex collagenase injection for the treatment of Dupuytren’s contracture by announcing the wholesale drug price: $3250.00 for a single treatment … The most common side effects with XIAFLEX® for the treatment of Dupuytren’s contracture include: XIAFLEX® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. Xiaflex is a prescription medication used to treat adults with Dupuytren’s contracture once a cord can be felt in the palm. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. This patient had a cord that could be felt causing a contracture of the MP joint of the left ring finger. All of them say they wished they asked more questions about the doctor who did the Xiaflex procedure. No personal information (including email addresses) about you or the recipient will be collected from this email notification features offered by Endo Pharmaceuticals. The cord was injected with XIAFLEX® at each location and a finger extension procedure was performed for each joint 48 hours later, MP=metacarpophalangeal PIP=proximal interphalangeal Individual results may vary. Xiaflex is an injectable formulation of purified collagenase derived from the bacterium, Clostridium histolyticum. For Dupuytren's contracture: “I was very disappointed with Xiaflex. In cases of Peyronie’s disease, the curvature of the penis must be more than 30 degrees. Lay your hand flat on the table. 83% (206 out of 249) of patients were satisfied with XIAFLEX® compared with 30% (38 out of 125) of patients with placebo. Your first follow-up visit with the doctor will be approximately 1 to 3 days after the injection. Xiaflex is also used to treat a related condition called Peyronie's disease in adult men. If your condition returns after treatment, nonsurgical XIAFLEX® may be used again. Management of Dupuytren’s disease—clear advice for an elusive condition. If you would like to email a link to this page of the website, provide your name and email address, as well as the recipients' email address(es), in the form fields below: Subject line: Information that may be of interest to you. Bayat A, McGrouther DA. Please see the full Prescribing Information, including Medication Guide. Lay your hand flat on the table. Do not bend or straighten the treated finger(s) yourself. The Dupuytren Contracture Institute is not against Xiaflex injections or surgery for Dupuytren’s contracture. Dupuytren’s contracture is a disease that causes your finger(s) to bend inward. Raise each finger up one at a time and hold for 5 seconds. Feldman G, Rozen N, Rubin G. Dupuytren's contracture: current treatment methods. Visalia California Orthopedic Surgeon Doctors physician directory - Read about Dupuytren's contracture treatment options: Xiaflex injection, needle aponeurotomy, ultrasound, and cortisone injection. Exhaustive, this chart gives the highlights of the pros and cons of each treatment method of your condition may! Surgery for Dupuytren 's contracture treatment Xiaflex extension procedure was performed 48 hours later may come no... Unaffected hand to gently straighten the affected finger 10 times, holding for 5 seconds known if Xiaflex is! 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